Vitamin D is Linked to Carotid Intima-Media Thickness and Immune Reconstitution in HIV-Positive Individuals
Key result
Lower vitamin D in HIV patients links to ~11-fold higher odds of above-median CCA IMT.
- OR 10.62
- 95% CI 1.37-82.34
- P<0.01
- n=183
Why the study?
Is vitamin D status associated with carotid intima-media thickness and immune reconstitution in HIV-positive patients on antiretroviral therapy?
Population
149 HIV-positive patients on antiretroviral therapy (56 with carotid IMT measured) and 34 healthy controls
Comparison
Vitamin D status vs Healthy controls and lower vs. higher vitamin D…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports vitamin D–cIMT link in treated HIV; hypothesis-generating and should not yet change practice.
Study Design
Type
Cross-Sectional (n=183)
Structured PICO
Is vitamin D status associated with carotid intima-media thickness and immune reconstitution in HIV-positive patients on antiretroviral therapy?
P
Population
183 participants, comprising 149 HIV-positive patients on antiretroviral therapy and 34 healthy controls, assessed in a cross-sectional study.
E
Exposure
Vitamin D status (fasting 25-hydroxyvitamin D levels)
C
Comparator
Healthy controls (for baseline levels) and lower vs. higher vitamin D levels within the HIV-positive cohort
O
Outcome
Common carotid artery (CCA) intima-media thickness (IMT) and CD4(+) T-cell restorationsurrogate
Main Result
Odds Ratio: 10.62 (95% CI 1.37–82.34)
p-value: p=<0.01
Lower vitamin D levels in HIV-positive patients on antiretroviral therapy are associated with increased carotid intima-media thickness and poorer immune reconstitution, suggesting a potential role in HIV-related cardiovascular disease.
Cite This Study
Ross et al. (2010) conducted a cross-sectional in HIV infection (n=183). Lower 25-hydroxyvitamin D levels vs. Higher 25-hydroxyvitamin D levels was evaluated on Common carotid artery intima-media thickness above the median (OR 10.62, 95% CI 1.37-82.34, p=<0.01). Lower vitamin D levels in HIV-positive patients were associated with higher odds of common carotid artery intima-media thickness above the median (OR 10.62; 95% CI 1.37-82.34; P<0.01).