Key result
Treated HIV-infected patients had higher carotid IMT and inflammatory markers than healthy controls, with soluble VCAM-1, myeloperoxidase, and TNF-alpha associated with internal carotid artery IMT.
Why the study?
Are inflammatory and endothelial activation markers associated with increased carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy?
Population
73 HIV-infected patients receiving antiretroviral therapy and 21 healthy control subjects
Design
Cross-sectional
Authors
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May link endothelial activation to subclinical atherosclerosis in treated HIV; hypothesis-generating, should not yet change practice.
Cross-Sectional (n=94)
Are inflammatory and endothelial activation markers associated with increased carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy?
HIV-infected patients on antiretroviral therapy exhibit increased carotid IMT and inflammatory markers, which are associated with endothelial activation, suggesting a role for inflammation in their elevated cardiovascular disease risk.
Ross et al. (2009) conducted a cross-sectional in HIV infection (n=94). HIV infection receiving antiretroviral therapy vs. Healthy control subjects was evaluated on Carotid IMT, proinflammatory cytokines, and endothelial activation biomarkers. Treated HIV-infected patients had higher carotid IMT and inflammatory markers than healthy controls, with soluble VCAM-1, myeloperoxidase, and TNF-alpha associated with internal carotid artery IMT.
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