Adaptation to the chicken embryo of a virus strain of infectious bursal disease resulted in a reduction in virulence. After 60 passages the strain was attenuated enough to be used as a vaccine. The attenuation proved adequately stable. If given orally in the drinking water, the strain induced the development of neutralising and precipiting antibodies and a strong resistance against the disease. Promising results have also been obtained in the field.
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Rinaldi et al. (1974) studied this question.
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