Why the study?
Does iodixanol reduce radiocontrast-induced nephropathy compared to iopamidol in patients with CKD undergoing cardiac angiography or percutaneous coronary interventions?
RCT (n=482)
Double-blind
randomized
Yes
Does iodixanol reduce radiocontrast-induced nephropathy compared to iopamidol in patients with CKD undergoing cardiac angiography or percutaneous coronary interventions?
Absolute Event Rate: 6.7% vs 4.4%
p-value: p=NS
In patients with CKD undergoing cardiac angiography or PCI, iodixanol did not significantly reduce the incidence of radiocontrast-induced nephropathy compared to iopamidol.
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Eberhard Ritz (2008) conducted an RCT in Chronic kidney disease undergoing cardiac angiography or percutaneous coronary interventions (n=482). Iodixanol vs. Iopamidol was evaluated on Increase in serum creatinine >0.5 mg/dl (p=NS).
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