Key result
Iopromide matches iodixanol with similarly low CIN rates in patients undergoing coronary procedures.
Why the study?
The comparative nephrotoxicity of low-osmolar iopromide versus iso-osmolar iodixanol in patients with moderate renal dysfunction undergoing coronary angiography or PCI was unclear.
Does iopromide compared to iodixanol reduce contrast-induced nephropathy in renally impaired patients undergoing cardiac catheterisation?
Population
562 Chinese patients with moderate renal dysfunction undergoing coronary angiography or PCI
Comparison
Iopromide versus iodixanol with rigorous hydration
Design
Multi-centre randomised double-blind study
Follow-up
3 days
Authors
Loading...
Supports either agent with hydration in moderate CKD; confirms equivalence of low- and iso-osmolar contrasts in this RCT population.
RCT (n=562)
Double-blind
randomised
Yes
Does iopromide compared to iodixanol reduce contrast-induced nephropathy in renally impaired patients undergoing cardiac catheterisation?
Absolute Event Rate: 0.4% vs 0.3%
p-value: p=statistically insignificant
In patients with moderate renal dysfunction undergoing cardiac catheterization with rigorous hydration, there is no significant difference in nephrotoxicity between iopromide and iodixanol.
Chen et al. (2012) conducted an RCT in Moderate renal dysfunction (n=562). Iopromide vs. Iodixanol was evaluated on Contrast-induced nephropathy (CIN) on day 3, defined as a post-dose increase in serum creatinine (SCr) of ≥50% from baseline (p=statistically insignificant). Iopromide and iodixanol resulted in similarly low rates of contrast-induced nephropathy (0.4% vs 0.3%) in patients with moderate renal dysfunction undergoing coronary angiography or PCI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: