July 1, 1958Circulation ResearchOpen Access

Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K 42 and Incidence of Atrial Fibrillation

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Key result

Temperature, sodium, potassium, and quinidine alter ion fluxes and AF incidence in isolated rabbit atria.

Population

Isolated rabbit atria

Design

Preclinical

Authors

WHWilliam C. HollandNational Oceanic and Atmospheric Administration RKRichard L. KleinMedical University of South Carolina

Discussion

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Implication

Preclinical rabbit atria data warrant no clinical AF changes; leaves open ion flux modulation for in vivo translation.

Structured PICO

Population

Isolated rabbit atria

Intervention

Temperature changes, K and Na concentration changes, and quinidine

Outcome

Transmembrane ion fluxes (K 42) and incidence of atrial fibrillationsurrogate

This preclinical study investigates the effects of temperature, ion concentrations, and quinidine on transmembrane fluxes and atrial fibrillation in isolated rabbit atria.

Cite This Study

Holland et al. (1958) studied this question. Temperature, sodium and potassium concentrations, and quinidine affect transmembrane ion fluxes and the incidence of atrial fibrillation in isolated rabbit atria.

synapsesocial.com/papers/6aa555d7f8a2a3c96b395918 https://doi.org/10.1161/01.res.6.4.516

Topics

Atrial fibrillation Persistent AF management

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Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K 42 and Incidence of Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of Temperature, Na and K Concentration and Quinidine on Transmembrane Flux of K 42 and Incidence of Atrial Fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider