What is the clinical evidence from this study?

Study design: Other. Intervention: Quinidine. Primary outcome: Unidirectional fluxes of Na and K.

What does this research mean for the field?

Quinidine rapidly inhibits sodium entry to secondarily depress potassium efflux, while also depressing membrane permeability to potassium and markedly inhibiting active transport in atrial tissue. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1960Circulation ResearchOpen Access

Quinidine and Unidirectional Cation Fluxes in Atria

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Key result

Quinidine rapidly inhibits Na entry and secondarily depresses K efflux in isolated rabbit atria.

Authors

RKRichard L. KleinMedical University of South Carolina WHWilliam C. HollandNational Oceanic and Atmospheric Administration BTBetty TinsleyVanderbilt University

Discussion

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Implication

Quinidine's atrial Na/K effects in rabbit tissue extend mechanistic insights; leaves open human translation and clinical relevance.

PICO

Intervention / Comparator

Quinidine

Primary Outcome

Unidirectional fluxes of Na and K

Cite This Study

Klein et al. (1960) studied this question. Quinidine was evaluated on Unidirectional fluxes of Na and K. Quinidine caused a rapid inhibition of Na entry, secondarily depressing K efflux, and depressed membrane permeability to K and active transport in isolated rabbit atria.

synapsesocial.com/papers/6aa555d7f8a2a3c96b395916 https://doi.org/10.1161/01.res.8.1.246

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Quinidine and Unidirectional Cation Fluxes in Atria

Discussion

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Implication

PICO

Cite This Study

Quinidine and Unidirectional Cation Fluxes in Atria

Discussion

Member takes

Implication

PICO

Cite This Study

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