Key result
Elevated UACR in non-diabetics is linked to a ~9-fold higher prevalence of triple-vessel CAD.
Why the study?
CAD is a leading cause of mortality and public health concern, prompting investigation into new biomarkers such as ACR to assess CAD severity in non-diabetic patients.
Does elevated urinary albumin creatinine ratio correlate with the severity of coronary artery disease in non-diabetic patients?
Cross-Sectional (n=101)
No
Does elevated urinary albumin creatinine ratio correlate with the severity of coronary artery disease in non-diabetic patients?
Absolute Event Rate: 67.6% vs 7.5%
p-value: p=<0.001
Elevated urinary albumin creatinine ratio is significantly associated with the severity of coronary artery disease in non-diabetic patients.
May warrant UACR monitoring in non-diabetics; leaves open whether it improves CAD risk stratification.
Background: Coronary artery disease (CAD) is leading cause of mortality worldwide. CAD accounts for 20% of all deaths in the South Asia region. The burden of CAD is emerging as a public health concern in developing countries like Bangladesh. There are some new biomarkers for detection of CAD. The aim of this study was to find out the relationship between ACR and severity of coronary artery disease in non-diabetic.Material & Methods:This cross-sectional analytical study was conducted in the department of cardiology, National Heart Foundation Hospital and Research Institute from April, 2018 to March, 2019. Purposive sampling was done to select a total 101 study subjects. Data were collected in a predesigned data collection form through clinical history, examination, laboratory findings and coronary angiogram report. Study population was divided into two groups: Group–A: Non-diabetic patients with ACR > 30mg/g Group–B: Non-diabetic patients with ACR ≤ 30mg/g.Results:Participants had a mean age of 52.5 ± 9.9 years with 75.24% men. Group A patients had higher ACR level (49.98±15.83 vs 13.36±7.08; p<0.01) than group B patients. Relation between urinary ACR and severity of CAD remained significant. Conclusions:In this study, there found a significant relationship in ACR and severity of coronary artery disease in non-diabetic patients.
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Hasan et al. (2022) conducted a cross-sectional in Ischemic Heart Disease (IHD) / Coronary Artery Disease (CAD) (n=101). Urinary Albumin Creatinine Ratio (ACR) ≥ 30 mg/g vs. Urinary Albumin Creatinine Ratio (ACR) < 30 mg/g was evaluated on Severity of coronary artery disease (triple vessel disease involvement) (p=<0.001). An elevated urinary albumin creatinine ratio (≥30 mg/g) in non-diabetic patients was significantly associated with more severe coronary artery disease, including a higher prevalence of triple vessel disease (67.6% vs 7.5%, p<0.001).
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