Key result
Cytopathic effect and reverse transcriptase detected in ~13% of multiple sclerosis patients versus zero healthy controls.
Why the study?
Is there evidence of retrovirus (cytopathic effect and reverse transcriptase) in peripheral blood mononuclear cells of patients with multiple sclerosis compared to healthy controls?
Case-Control
Is there evidence of retrovirus (cytopathic effect and reverse transcriptase) in peripheral blood mononuclear cells of patients with multiple sclerosis compared to healthy controls?
Absolute Event Rate: 13.3% vs 0%
The findings suggest the possible presence of a new human retrovirus in a small subset of patients with multiple sclerosis.
May indicate retroviral markers in a minority of MS cases; hypothesis-generating and requires larger studies before any clinical relevance.
Presence of cytopathic effect and enzyme reverse transcriptase in cultures of peripheral blood mononuclear cells is described in 2 of 15 patients with multiple sclerosis and none of healthy controls. These findings might indicate: the presence of a new human retrovirus in these individuals, despite the low detection rate, and the shortcomings inherent in methodology used for detection of known human retroviruses in the study of new groups of diseases, such as those with possible autoimmune background.
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Kam‐Hansen et al. (1989) conducted a case-control in Multiple sclerosis. Multiple sclerosis vs. Healthy controls was evaluated on Presence of cytopathic effect and enzyme reverse transcriptase in cultures of peripheral blood mononuclear cells. Cytopathic effect and enzyme reverse transcriptase were detected in peripheral blood mononuclear cell cultures of 2 of 15 patients with multiple sclerosis, compared to none in healthy controls.
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