Key result
Increased admission ΔpCO2 is linked to ~10-fold higher mortality versus a normal gradient.
Authors
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May aid early risk stratification in shock; hypothesis-generating and should not yet change practice.
Cohort (n=103)
Absolute Event Rate: 51% vs 5%
p-value: p=< 0.0001
Jakob et al. (2008) conducted a cohort in acute respiratory or circulatory failure (n=103). Increased mucosal-arterial pCO2 gradient (ΔpCO2) vs. Normal ΔpCO2 was evaluated on mortality (p=< 0.0001). An increased mucosal-arterial pCO2 gradient (ΔpCO2) at admission was associated with significantly higher mortality compared to a normal gradient (51% vs. 5%; P<0.0001).
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