Key result
Normotensive pregnancy is linked to a ~79% increase in supine SBP variability from early to late pregnancy.
Why the study?
Does normotensive pregnancy alter baroreceptor sensitivity for heart rate and sympathovagal balance compared to non-pregnant controls?
Population
16 normotensive pregnant women and 10 normotensive non-pregnant controls
Comparison
Normotensive pregnancy vs Normotensive non-pregnant state (controls)
Design
Cohort
Follow-up
Through pregnancy and puerperium
Authors
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These autonomic shifts should not yet change practice; leaves open prospective links to adverse outcomes.
Observational (n=26)
Does normotensive pregnancy alter baroreceptor sensitivity for heart rate and sympathovagal balance compared to non-pregnant controls?
Effect estimate: 79% increase (95% CI 30%, 145%)
p-value: p=<0.001
Normotensive pregnancy is associated with a marked decrease in supine baroreflex sensitivity and vagal withdrawal, which normalizes postpartum.
Blake et al. (2000) conducted an observational in Normotensive pregnancy (n=26). Pregnancy vs. Non-pregnant controls and early pregnancy baseline was evaluated on Supine total systolic blood pressure (SBP) variability (79% increase, 95% CI 30%, 145%, p=<0.001). Normotensive pregnancy is associated with a 79% increase in supine total SBP variability (95% CI 30-145%; P<0.001) and a 50% fall in supine baroreflex sensitivity from early to late pregnancy.
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