Key result
Food intake increases aldosterone metabolic clearance by ~61% versus fasting.
Why the study?
Does food intake affect the metabolic clearance rate of aldosterone in adult individuals?
Does food intake affect the metabolic clearance rate of aldosterone in adult individuals?
Effect estimate: 29% increase
Absolute Event Rate: 2182% vs 1357%
p-value: p=<0.001
Food intake significantly increases the metabolic clearance rate of aldosterone, an effect similar in magnitude and duration to food-induced increases in hepatic blood flow.
May alter postprandial aldosterone level interpretation; leaves open clinical relevance for diagnostics or therapy.
The effect of eating on the metabolic clearance rate (MCR) of aldosterone was investigated in 10 adult individuals. 3H-aldosterone was infused continuously over a period of 5 h while the subjects remained supine. Three h after the start of the infusion, each subject ate a bowl of soup. The MCR of aldosterone, before and after the intake of food, was calculated by dividing the rate of infusion of 3H-aldosterone by the mean concentration of under the same conditions but without eating. The MCR of aldosterone (mean +/- 1 SD) was 1284 +/- 513 L/24 h before food intake and 2182 +/- 180 L/24 h after food intake in the 10 individuals who ate. The MCR in the 11 subjects who did not eat was 1363 +/- 446 and 1357 +/- 434 during the same periods (p greater than 0.05). The 29% increase in the MCR induced by eating was highly significant (p less than 0.001); it was similar in magnitude and duration to a previously reported effect of food intake on the hepatic blood flow (13).
No takes yet. Share an insight, caveat, or question.
Akesode et al. (1977) studied this question. Food intake (a bowl of soup) vs. Fasting (no food intake) was evaluated on Metabolic clearance rate (MCR) of aldosterone (29% increase, p=<0.001). Food intake significantly increased the metabolic clearance rate of aldosterone compared to fasting (2182 vs 1357 L/24 h; p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: