Key result
Anephric patients demonstrated an unexpectedly high aldosterone metabolic clearance rate (2700 ± 265 1/24 h) compared to normal volunteers (1600 ± 57 1/24 h).
Why the study?
Is the steroid metabolic clearance rate altered in anephric patients compared to normal volunteers?
Observational
Is the steroid metabolic clearance rate altered in anephric patients compared to normal volunteers?
Anephric patients exhibit an unexpectedly high metabolic clearance rate of aldosterone, potentially driven by high hepatic plasma flow due to high cardiac output.
Answers are grounded in this paper and cite their sources.
Associated with higher aldosterone clearance in anephric patients; leaves open hepatic flow mechanisms pending prospective validation.
The control of plasma aldosterone level depends on the secretion rate and on the metabolic clearance rate (MCR) of the hormone. The rate of aldosterone metabolism was measured in 6 anephric patients in comparison with normal volunteers. Unexpected high aldosterone MCR's were found in the anephric patients: 2700 ± 265 1/24 h (M ± sem), as compared to the normals (1600 ± 57). Passive 45° tilting did not significantly change aldosterone MCR's in both the normal and anephric patients. This increase in aldosterone MCR might be explained by a high hepatic plasma flow due to a high cardiac output. The haemodynamic condition of these patients could also explain the high testosterone MCR found in 3 male anephric patients, although testosterone-oestradiol binding globulin was in the high normal male range.
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Corvol et al. (1974) conducted an observational in Anephric state. Anephric state vs. Normal volunteers was evaluated on Aldosterone metabolic clearance rate (MCR). Anephric patients demonstrated an unexpectedly high aldosterone metabolic clearance rate (2700 ± 265 1/24 h) compared to normal volunteers (1600 ± 57 1/24 h).
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