Why the study?
Does infusion of angiotensin II cause abnormal decreases in the metabolic clearance of aldosterone in patients with essential hypertension compared to normal subjects?
Population
12 patients with essential hypertension and 10 normal subjects (n=22)
Comparison
Infusion of angiotensin II vs Normal subjects receiving the same infusion, and…
Design
Other
Authors
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No difference in aldosterone clearance supports secretion as driver of Ang II response in hypertension; leaves open confirmation in prospective studies.
Does infusion of angiotensin II cause abnormal decreases in the metabolic clearance of aldosterone in patients with essential hypertension compared to normal subjects?
The exaggerated plasma aldosterone response to angiotensin II in essential hypertension is driven by increased adrenal secretion rather than reduced metabolic clearance.
Wisgerhof et al. (1979) studied this question.
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