What question did this study set out to answer?

The study examines the effect of adrenocortical hormones, particularly aldosterone and angiotensin, on hypertension and sodium regulation.

Adrenocortical Hormones in Human Hypertension and Their Relation to Angiotensin

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Randomized trial investigates adrenocortical hormones in hypertension, suggesting new insights for treatment.

The study examines the effect of adrenocortical hormones, particularly aldosterone and angiotensin, on hypertension and sodium regulation.
Infusion of epinephrine, norepinephrine, and phenylephrine in glucose for 7-10 hours to observe urinary aldosterone excretion changes.
Angiotensin II infusions were conducted to measure sodium excretion, Na/K ratio, and aldosterone levels in normal subjects and patients with hypertension.
Epinephrine, norepinephrine, and phenylephrine infusion decreased or had little effect on urinary aldosterone excretion.
Angiotensin II infusion significantly increased aldosterone excretion while decreasing sodium excretion and the Na/K ratio in normal subjects.
In hypertensive patients, angiotensin stimulated aldosterone excretion but raised sodium output and improved the Na/K ratio.

Genest et al. (1961) studied this question.

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