Why the study?
Does the pressor response to tyramine, noradrenaline, and angiotensin differ in hypertensive patients with aldosteronism and low plasma renin compared to other groups, and does it change after adrenal surgery?
Population
36 subjects including 9 patients with hypertension, aldosteronism and low plasma renin, 5 patients with…
Comparison
Pressor tests with tyramine, noradrenaline, and… vs Normotensive controls, patients with…
Design
Cohort
Authors
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Altered pressor responses in aldosteronism may reflect reversible adrenergic dysfunction; leaves open clinical utility of tyramine testing pending prospective studies.
Does the pressor response to tyramine, noradrenaline, and angiotensin differ in hypertensive patients with aldosteronism and low plasma renin compared to other groups, and does it change after adrenal surgery?
Hypertensive patients with aldosteronism and low plasma renin exhibit altered adrenergic function, characterized by reduced tyramine responsiveness that normalizes after adrenal surgery.
Distler et al. (1970) studied this question.
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