Key result
Novel loci near RPS23P3 and NDUFA12 are linked to sex-specific memory and executive function decline.
Why the study?
Many complex traits and diseases show sex-specific biases in clinical presentation and prevalence, but the sex-specific genetic architecture of cognitive decline across cognitive domains was not well understood.
Population
3021 older adults aged ≥ 65 years (female = 1545, male = 1476) from three prospective cohorts
Comparison
Female vs male sex-stratified genetic associations
Design
Sex-stratified genome-wide meta-analysis
Authors
Loading...
Novel sex-specific loci for memory (males) and executive decline (females) identified; leaves open replication and clinical translation in cognitive aging.
Meta-Analysis (n=3,021)
Yes
Effect estimate: β 0.19 (males); β 0.28 (females)
p-value: p=4.10E-08 (males); 9.35E-08 (females)
Sex-stratified genome-wide meta-analysis identified novel sex-specific genetic loci associated with cognitive decline in older adults.
Acharya et al. (2025) conducted a meta-analysis in cognitive decline (n=3,021). Genetic loci (rs6851574 and rs11107823) was evaluated on Decline of memory in males and decline of executive function in females (β 0.19 (males); β 0.28 (females), p=4.10E-08 (males); 9.35E-08 (females)). Novel loci were associated with memory decline in males near RPS23P3 (β=0.19, P=4.10E-08) and executive function decline in females near NDUFA12 (β=0.28, P=9.35E-08).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: