Key result
Simulated antegrade flow in Fontan circulation increases pulmonary artery pulsatility ~140% but worsens energy loss.
Why the study?
Does adding antegrade flow through a stenosed main pulmonary artery improve pulmonary flow pulsations in a computational model of Fontan circulation?
Does adding antegrade flow through a stenosed main pulmonary artery improve pulmonary flow pulsations in a computational model of Fontan circulation?
Computational fluid dynamics modeling demonstrates that preserving antegrade flow in Fontan circulation increases pulmonary flow pulsatility but also increases energy loss.
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May boost pulmonary pulsatility in Fontan models; leaves open whether added energy loss offsets any clinical benefit.
Ghoreyshi et al. (2012) studied Single ventricle heart disease (n=1). Antegrade Flow (AF) through stenosed Main Pulmonary Artery (MPA) vs. Ordinary TCPC operation (0% AF) was evaluated on Pulsatility Index (PI) and energy loss. Simulating antegrade flow through a stenosed main pulmonary artery in Fontan circulation increased the left pulmonary artery pulsatility index by up to 140%, while increasing energy loss by up to 67%.
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