Key result
Higher dietary antioxidant scores are linked to lower ePWV and heart vascular age.
Why the study?
The composite dietary antioxidant index evaluates antioxidant consumption and lowers age-related disease risk, but its exact relationship with vascular age has not been established.
Does a higher composite dietary antioxidant index (CDAI) improve estimated pulse wave velocity and heart vascular age in US adults?
Cross-Sectional (n=41,380)
Does a higher composite dietary antioxidant index (CDAI) improve estimated pulse wave velocity and heart vascular age in US adults?
Effect estimate: β = -0.008 for ePWV, β = -0.080 for heart vascular age
p-value: p=<0.001 for ePWV, 0.033 for heart vascular age
Higher dietary antioxidant intake, as measured by the CDAI, is associated with reduced arterial stiffness and lower vascular age in US adults.
Supports antioxidant-rich diets for vascular metrics; leaves open whether CDAI modification improves arterial stiffness in trials.
BACKGROUND: The composite dietary antioxidant index (CDAI) is a useful tool for evaluating antioxidant consumption and has been shown to effectively lower the risk of age-related diseases. However, the exact relationship between the CDAI and vascular age has yet to be established. METHODS: We performed a cross-sectional study examining the association between dietary antioxidants, as measured by the CDAI, and estimated pulse wave velocity (ePWV) and heart vascular age in 41,380 adults based in the United States using data from the National Health and Nutrition Examination Survey from 1999 to 2018. Multivariable linear regression models, restricted cubic splines, and subgroup analysis were used to examine the associations between the CDAI and ePWV and heart vascular age. RESULTS: This study included 41,380 participants with a mean ± SD age of 50 ± 18 years. After adjusting for confounding factors, multiple linear regression analysis revealed that higher CDAI scores were independently associated with lower ePWV (β = -0.008, P < 0.001) and lower heart vascular age (β = -0.080, P = 0.033). Restricted cubic spline analysis showed that the CDAI was negatively associated with ePWV and heart vascular age. No statistical interaction was observed within any subgroups of the CDAI and ePWV and heart vascular age. CONCLUSION: Higher CDAI scores were associated with lower ePWV and heart vascular age in US adults.
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Zhao et al. (2025) reported a cross-sectional. Composite dietary antioxidant index (CDAI) was evaluated on estimated pulse wave velocity (ePWV) and heart vascular age (β = -0.008 for ePWV, β = -0.080 for heart vascular age, p=<0.001 for ePWV, 0.033 for heart vascular age). Higher composite dietary antioxidant index scores were independently associated with lower estimated pulse wave velocity (β = -0.008, P<0.001) and lower heart vascular age (β = -0.080, P=0.033).
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