Key result
Reduced left ventricular ejection fraction (<40%) measured during hospitalization for acute myocardial infarction was independently associated with a significantly lower KCCQ clinical summary score (mean difference -15.4) 2.5 years later compared to normal LVEF.
Why the study?
Does reduced LVEF during hospitalization for acute MI predict worse health-related quality of life 2.5 years later?
Cohort (n=256)
Yes
Does reduced LVEF during hospitalization for acute MI predict worse health-related quality of life 2.5 years later?
Mean Difference: -15.4 (95% CI -22.6–-8.3)
Absolute Event Rate: 68% vs 85%
p-value: p=<0.001
Lower LVEF measured during hospitalization for acute MI is independently associated with worse health-related quality of life 2.5 years later.
BACKGROUND: The objective was to explore the relationship between left ventricular ejection fraction (LVEF) assessed during hospitalization for acute myocardial infarction (MI) and later health-related quality of life (HRQoL). METHODS: We used multivariable linear regression to assess the relationship between LVEF and HRQoL in 256 MI patients who responded to the Kansas City Cardiomyopathy Questionnaire (KCCQ), the EQ-5D Index, and the EuroQol Visual Analogue Scale (EQ-VAS) 2.5 years after the index MI. RESULTS: 167 patients had normal LVEF (>50%), 56 intermediate (40%-50%), and 33 reduced (<40%). The mean (SD) KCCQ clinical summary scores were 85 (18), 75 (22), and 68 (21) (p <0.001) in the three groups, respectively. The corresponding EQ-5D Index scores were 0.83 (0.18), 0.72 (0.27), and 0.76 (0.14) (p = 0.005) and EQ-VAS scores were 72 (18), 65 (21), and 57 (20) (p = 0.001). In multivariable linear regression analysis age > or = 70 years, known chronic obstructive pulmonary disease (COPD), subsequent MI, intermediate LVEF, and reduced LVEF were independent determinants for reduced KCCQ clinical summary score. Female sex, medication for angina pectoris at discharge, and intermediate LVEF were independent determinants for reduced EQ-5D Index score. Age > or = 70 years, COPD, and reduced LVEF were associated with reduced EQ-VAS score. CONCLUSION: LVEF measured during hospitalization for MI was a determinant for HRQoL 2.5 years later.
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Pettersen et al. (2008) conducted a cohort in Acute myocardial infarction (n=256). Reduced left ventricular ejection fraction (<40%) vs. Normal left ventricular ejection fraction (>50%) was evaluated on KCCQ clinical summary score at 2.5 years (MD -15.4, 95% CI -22.6 to -8.3, p=<0.001). Reduced left ventricular ejection fraction (<40%) measured during hospitalization for acute myocardial infarction was independently associated with a significantly lower KCCQ clinical summary score (mean difference -15.4) 2.5 years later compared to normal LVEF.
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