Key result
Dantrolene sodium reduces twitch height by ~59% in isolated mouse soleus muscle versus untreated controls.
Dantrolene sodium inhibits the release of calcium ions involved in excitation-contraction coupling in mammalian skeletal muscle, contrasting with the effects of sodium thiocyanate.
Dantrolene's EC-coupling inhibition in mouse skeletal muscle is hypothesis-generating; leaves open translation to human cardiac or clinical use.
1 A combination of electrical and pharmacological stimulation has been used to compare the effects of sodium thiocyanate and dantrolene sodium on the excitation-contraction coupling (ECC) mechanism of the mouse soleus muscle. 2 Thiocyanate prolonged the 'active state' after electrical stimulation and increased the response to 8 mM caffeine and 80 mM KCl. Dantrolene had an opposite effect to thiocyanate on all the indices studied. 3 It is concluded that the mechanism of action of dantrolene is by inhibition of the release of the calcium ions involved in the ECC mechanism, probably at the level of the transverse tubules.
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R. F. W. Moulds (1977) studied Normal mammalian skeletal muscle (in vitro). Dantrolene sodium vs. Normal solei (untreated) was evaluated on Twitch height (g) (p=<0.001). Dantrolene sodium significantly reduced the twitch height of isolated mouse soleus muscle compared to normal untreated muscle (0.80 g vs 1.93 g, p<0.001).
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