Why the study?
Does dantrolene modify myocardial contraction and relaxation in rat left ventricular papillary muscles in vitro?
Population
Rat left ventricular papillary muscles in vitro
Comparison
Dantrolene (10(-5)-10(-3) M) vs Control values
Design
Preclinical
Authors
Loading...
Dantrolene may exert negative inotropy at low calcium in rat myocardium in vitro; leaves open translation to human cardiac function.
Does dantrolene modify myocardial contraction and relaxation in rat left ventricular papillary muscles in vitro?
Dantrolene induces a moderate negative inotropic effect in rat myocardium at low calcium concentrations, likely via decreased transsarcolemmal calcium entry, without affecting sarcoplasmic reticulum function.
Fratéa et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: