Key result
Dantrolene pre-treatment significantly inhibited inducible bi-directional ventricular tachycardia and improved exercise tolerance in a CPVT-associated RyR2R2474S/+ knock-in mouse model.
Why the study?
Does dantrolene prevent inducible ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model of CPVT?
Does dantrolene prevent inducible ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model of CPVT?
p-value: p=<0.01
Dantrolene prevents catecholaminergic polymorphic ventricular tachycardia in a RyR2 knock-in mouse model, suggesting a potential therapeutic role by inhibiting Ca2+ leak.
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Supports dantrolene trials in CPVT; leaves open human translation from this animal model and should not change practice.
Kobayashi et al. (2010) studied Catecholaminergic polymorphic ventricular tachycardia (CPVT) (n=24). Dantrolene vs. Untreated KI mice / WT mice was evaluated on Inducible bi-directional ventricular tachycardia (VT) after epinephrine injection or exercise (p=<0.01). Dantrolene pre-treatment significantly inhibited inducible bi-directional ventricular tachycardia and improved exercise tolerance in a CPVT-associated RyR2R2474S/+ knock-in mouse model.
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