Key result
In isolated calcium-overloaded hamster left ventricles, dantrolene sodium improved calcium tolerance, exerted positive inotropic effects, and decreased diastolic stiffness.
Why the study?
Does dantrolene sodium improve systolic and diastolic function in isolated calcium-overloaded hamster left ventricles?
Population
Isolated hamster left ventricles (n=19)
Comparison
Dantrolene sodium (11.8 mumol/L) vs Absence of dantrolene sodium (control)
Design
Preclinical
Authors
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Dantrolene may merit further preclinical testing in calcium-handling disorders; leaves open any role in human systolic or diastolic dysfunction.
Does dantrolene sodium improve systolic and diastolic function in isolated calcium-overloaded hamster left ventricles?
Dantrolene sodium improves calcium tolerance, exerts positive inotropic effects, and decreases diastolic stiffness in calcium-overloaded hamster left ventricles.
Satoh et al. (1997) studied Calcium-overloaded heart (n=19). Dantrolene sodium vs. Absence of dantrolene sodium (control) was evaluated on Left ventricular developed pressure and maximum rate of rise (max dP/dt). In isolated calcium-overloaded hamster left ventricles, dantrolene sodium improved calcium tolerance, exerted positive inotropic effects, and decreased diastolic stiffness.
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