Key result
Perfusion with dantrolene sodium produced no significant changes in cardiovascular parameters in isolated rat hearts, contradicting previous reports of myocardial depression.
Why the study?
Does dantrolene sodium cause myocardial depression in isolated, perfused rat hearts?
Population
Isolated, perfused rat hearts using a modified Langendorff preparation with 3.5% bovine albumin in buffered…
Comparison
Perfusion with dantrolene sodium solution vs Baseline parameters before perfusion
Design
Preclinical
Authors
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No myocardial depression with dantrolene in isolated rat hearts; challenges prior reports but leaves open clinical translation.
Does dantrolene sodium cause myocardial depression in isolated, perfused rat hearts?
Dantrolene sodium has no significant effect on cardiovascular parameters in the isolated, perfused rat heart, contradicting previous reports of marked myocardial depression.
Gollan et al. (1979) studied Isolated, perfused heart (n=9). Dantrolene sodium vs. Baseline (before perfusion) was evaluated on Cardiovascular changes (heart rate, coronary flow, resting length, intraventricular pressure, force displacement and their first derivatives). Perfusion with dantrolene sodium produced no significant changes in cardiovascular parameters in isolated rat hearts, contradicting previous reports of myocardial depression.