Why the study?
Does the combination of intravenous dantrolene and verapamil affect atrioventricular conduction and cardiovascular performance in anesthetized dogs?
Population
Chloralose-urethane anesthetized dogs
Comparison
Intravenous dantrolene sodium and verapamil… vs Baseline measurements and alternate sequence of…
Design
Preclinical
Authors
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May signal dantrolene-verapamil hemodynamic interaction in dogs; hypothesis-generating and should not change practice.
Does the combination of intravenous dantrolene and verapamil affect atrioventricular conduction and cardiovascular performance in anesthetized dogs?
The combination of intravenous dantrolene and verapamil enhances myocardial depression in an anesthetized dog model, suggesting potential adverse hemodynamic interactions.
Lynch et al. (1986) studied this question.
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