Key result
Repaired aortic coarctation linked to increased 18F-FDG uptake vs controls, indicating sustained late wall inflammation.
Why the study?
Does 18F-FDG PET/CT imaging detect increased aortic wall inflammation in normotensive patients with repaired coarctation of aorta compared to matched controls?
Population
30 subjects total: 15 normotensive patients with successful surgically repaired coarctation of aorta without…
Comparison
18F-fluorodeoxyglucose positron emission… vs Age- and sex-matched control subjects
Design
Cross-sectional
Authors
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Sustained aortic inflammation after repair may inform surveillance; leaves open prospective validation of PET/CT for risk stratification.
Case-Control (n=30)
No
Does 18F-FDG PET/CT imaging detect increased aortic wall inflammation in normotensive patients with repaired coarctation of aorta compared to matched controls?
18F-FDG PET/CT imaging demonstrates that adult patients with repaired coarctation of the aorta have increased aortic wall inflammation, particularly in the descending thoracic aorta and those with bicuspid aortic valves, which correlates with systemic IL-6 levels.
Brili et al. (2018) conducted a case-control in Repaired Coarctation of Aorta (n=30). Repaired coarctation of aorta vs. Age- and sex-matched disease-free controls was evaluated on Global aortic 18F-FDG uptake (target-to-background ratio). Repaired coarctation of the aorta was associated with increased global aortic 18F-FDG uptake compared with matched controls, indicating sustained aortic wall inflammation late in adult life.
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