What does this research mean for the field?

Double filtration plasmapheresis and thermofiltration exhibit non-inferior efficacy and safety compared to low-density lipoprotein adsorptive apheresis for lipid removal in heterozygous familial hypercholesterolemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1996Artificial Organs

Evaluation of Double Filtration Plasmapheresis, Thermofiltration, and Low–Density Lipoprotein Adsorptive Methods by Crossover Test in the Treatment of Familial Hypercholesterolemia Patients

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Heterozygous familial hypercholesterolemia (n=5). Intervention: Double filtration plasmapheresis (DFPP) and thermofiltration (TFPP) vs. Low-density lipoprotein adsorptive (PA) method. Primary outcome: Removal rates of total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B.

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Key result

Double filtration plasmapheresis and thermofiltration are non-inferior to LDL adsorption for lipid removal in FH.

Why the study?

Do double filtration plasmapheresis and thermofiltration provide similar efficacy and safety compared to LDL adsorptive methods in patients with heterozygous familial hypercholesterolemia?

Study Design

Type

RCT (n=5)

Structured PICO

Do double filtration plasmapheresis and thermofiltration provide similar efficacy and safety compared to LDL adsorptive methods in patients with heterozygous familial hypercholesterolemia?

Population

5 patients with heterozygous familial hypercholesterolemia treated with 3 different apheresis methods in a crossover design.

Intervention

Double filtration plasmapheresis (DFPP) and thermofiltration (TFPP) (5 treatments each, 2-week interval, 4 L plasma processed)

Comparator

Low-density lipoprotein (LDL) adsorptive (PA) method (5 treatments, 2-week interval, 4 L plasma processed)

Outcome

Removal rates of total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein Bsurrogate

Double filtration plasmapheresis and thermofiltration are effective and safe alternatives to LDL adsorption for treating heterozygous familial hypercholesterolemia, with potentially greater removal of certain lipoproteins and fibrinogen.

Discussion

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Implication

May support DFPP and thermofiltration as alternatives in heterozygous FH; leaves open randomized confirmation of long-term outcomes.

Cite This Study

Suzuki et al. (1996) conducted an RCT in Heterozygous familial hypercholesterolemia (n=5). Double filtration plasmapheresis (DFPP) and thermofiltration (TFPP) vs. Low-density lipoprotein adsorptive (PA) method was evaluated on Removal rates of total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B. Double filtration plasmapheresis and thermofiltration were not inferior to the low-density lipoprotein adsorptive method for lipid removal in patients with familial hypercholesterolemia.

synapsesocial.com/papers/6aa57a9ac616a76b5feec505 https://doi.org/10.1111/j.1525-1594.1996.tb04448.x

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Evaluation of Double Filtration Plasmapheresis, Thermofiltration, and Low–Density Lipoprotein Adsorptive Methods by Crossover Test in the Treatment of Familial Hypercholesterolemia Patients

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Evaluation of Double Filtration Plasmapheresis, Thermofiltration, and Low–Density Lipoprotein Adsorptive Methods by Crossover Test in the Treatment of Familial Hypercholesterolemia Patients

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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