Key result
The Kuraray filter combination achieved similar LDL reduction compared to the Asahi combination (67% vs 66%), but the Asahi system experienced premature terminations due to saturation.
Why the study?
Does the Kuraray filter combination compared to the Asahi filter combination improve selectivity and prevent premature saturation during LDL apheresis in patients on chronic apheresis therapy?
Does the Kuraray filter combination compared to the Asahi filter combination improve selectivity and prevent premature saturation during LDL apheresis in patients on chronic apheresis therapy?
Absolute Event Rate: 67% vs 66%
Different membrane filters for LDL apheresis show similar LDL reduction but differ significantly in selectivity and sensitivity to saturation.
Supports preferring Kuraray filters to reduce interruptions; leaves open effects on long-term outcomes.
Membrane differential filtration is an accepted procedure for the extracorporeal removal of low-density lipoprotein (LDL). Reduction rates largely depend on the nature of the membranes and are ideally evaluated in a crossover study design. Four patients who had been treated by LDL apheresis for at least 6 months were included. Six consecutive weekly sessions (40 ml plasma/kg body weight) were scheduled per system (Plasmacure PS06/Evaflux Eval 5A [Kuraray] versus Plasmaflo OP05W/Cascadeflo AC1770 [Asahi]). Laboratory measurements indicated reductions of plasma concentrations for fibrinogen (37% [Kuraray] versus 44% [Asahi]), IgG (15% versus 20%), IgA (24% versus 28%), IgM (63% versus 53%), and total protein (11% versus 16%). Total cholesterol was eliminated by 52% versus 49%, LDL by 67% versus 66%, triglycerides by 56% versus 41%, and high-density lipoprotein by 10% versus 20%. Three therapies employing the Asahi filter combination were terminated prematurely due to saturation of the plasma fractionator. In conclusion, despite similar physical properties, the membranes differ significantly concerning selectivity and sensitivity to saturation.
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Matic et al. (2002) studied Patients requiring low-density lipoprotein (LDL) apheresis (n=4). Plasmacure PS06/Evaflux Eval 5A (Kuraray) filter combination vs. Plasmaflo OP05W/Cascadeflo AC1770 (Asahi) filter combination was evaluated on Reduction of plasma concentrations for LDL. The Kuraray filter combination achieved similar LDL reduction compared to the Asahi combination (67% vs 66%), but the Asahi system experienced premature terminations due to saturation.
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