Key result
Enovid therapy increases plasma fibrinogen by ~32% in young healthy subjects.
Why the study?
Does Enovid (norethynodrel and ethynylestradiol-3-methyl ether) affect plasma fibrinogen concentration in young normal human subjects?
Does Enovid (norethynodrel and ethynylestradiol-3-methyl ether) affect plasma fibrinogen concentration in young normal human subjects?
Effect estimate: 32.4% increase
p-value: p=<0.001
Enovid therapy significantly increases plasma fibrinogen in young normal subjects, suggesting a specific effect on the blood coagulation or fibrinolytic system.
No takes yet. Share an insight, caveat, or question.
May signal prothrombotic shift with oral steroids; hypothesis-generating for links to contraceptive thromboembolism.
Amundson et al. (1963) studied Healthy. Enovid was evaluated on plasma fibrinogen concentration (32.4% increase, p=<0.001). Enovid therapy in young normal human subjects caused a 32.4% increase in plasma fibrinogen (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: