Key result
Tailored DOAC therapy may optimize the balance between bleeding and thrombosis risks compared to fixed-dose regimens, particularly in patients with extremes of body weight or impaired kidney function.
Why the study?
Does tailored DOAC therapy based on drug levels improve the balance between bleeding and thrombosis compared to fixed-dose regimens in patients with thromboembolic diseases?
Population
Patients with thromboembolic diseases, including special populations such as those with extremes of body…
Comparison
Tailored direct oral anticoagulant therapy based… vs Fixed dose DOAC regimens
Design
Editorial
Authors
Loading...
This opinion article suggests that tailoring DOAC therapy based on drug levels, rather than using standard fixed doses, could potentially optimize the balance between bleeding and thrombosis risks, particularly in special populations.
Does tailored DOAC therapy based on drug levels improve the balance between bleeding and thrombosis compared to fixed-dose regimens in patients with thromboembolic diseases?
This opinion article suggests that tailoring DOAC therapy based on drug levels, rather than using standard fixed doses, could potentially optimize the balance between bleeding and thrombosis risks, particularly in special populations.
Toorop et al. (2020) conducted a review in Thromboembolic diseases. Tailored DOAC therapy vs. Fixed dose regimens was evaluated. Tailored DOAC therapy may optimize the balance between bleeding and thrombosis risks compared to fixed-dose regimens, particularly in patients with extremes of body weight or impaired kidney function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: