What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes mellitus (n=103). Intervention: Serum uric acid levels vs. Lower serum uric acid levels. Primary outcome: Carotid intima-media thickness (CIMT) (r = 0.779, p=0.001).

January 1, 2018Indian Journal of Endocrinology and MetabolismOpen Access

Serum uric acid levels in Type 2 diabetes mellitus: Is there a linear relationship with severity of carotid atherosclerosis?

Q: What does this research mean for the field?

Higher serum uric acid levels are strongly and positively associated with increased carotid intima-media thickness in patients with type 2 diabetes mellitus. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Higher serum uric acid is strongly linked to increased CIMT in patients with T2DM.

r = 0.779
P=0.001
n=103

Why the study?

Does serum uric acid level correlate with carotid intima-media thickness in patients with type 2 diabetes mellitus?

Population

103 patients with type 2 diabetes mellitus, aged 30-65 years at a tertiary care center in India. Excluded…

Design

Cross-sectional

Authors

RBRama BhatManipal Academy of Higher Education SVShantan VenishettyCARE Hospitals KRKV Rajagopal

Discussion

Member takes

Implication

Supports uric acid as atherosclerosis marker in T2DM; hypothesis-generating and needs prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=103)

Multicenter

Structured PICO

Does serum uric acid level correlate with carotid intima-media thickness in patients with type 2 diabetes mellitus?

Population

103 adults aged 30 to 65 years with type 2 diabetes mellitus, free from significant comorbidities and uric acid-lowering medications, evaluated in a cross-sectional study.

Outcome

Correlation between serum uric acid (SUA) levels and carotid intima-media thickness (CIMT)surrogate

Main Result

Effect estimate: r = 0.779

p-value: p=0.001

Serum uric acid levels are significantly and positively correlated with carotid intima-media thickness in patients with type 2 diabetes mellitus, suggesting a link with carotid atherosclerosis severity.

Limitations

The study includes a subset of the population which may not represent the entire population with respect to region or ethnicity.
This is a descriptive cross-sectional study with no control group.
Further studies are needed to establish uric acid as an independent risk factor for atherosclerosis.
Descriptive cross-sectional study with no control group
Subset of population which may not represent the entire population with respect to region or ethnicity
Cannot establish uric acid as an independent risk factor or prove causality

Cite This Study

Bhat et al. (2018) conducted a cross-sectional in Type 2 diabetes mellitus (n=103). Serum uric acid levels vs. Lower serum uric acid levels was evaluated on Carotid intima-media thickness (CIMT) (r = 0.779, p=0.001). Higher serum uric acid levels were strongly and positively associated with increased carotid intima-media thickness in patients with type 2 diabetes mellitus (r = 0.779, P = 0.001).

synapsesocial.com/papers/6aa581c62f265d5e947f1ebc https://doi.org/10.4103/ijem.ijem_641_17

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Serum uric acid levels in Type 2 diabetes mellitus: Is there a linear relationship with severity of carotid atherosclerosis?

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Serum uric acid levels in Type 2 diabetes mellitus: Is there a linear relationship with severity of carotid atherosclerosis?

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider