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Case report demonstrates platypnea-orthodeoxia caused by orthostatic ventilation-perfusion mismatching in progressive autonomic failure, indicating resolution following fluid challenge.
Platypnea-orthodeoxia has been described in patients with pulmonary shunts, intracardiac shunts, and severe lung disease. We report a case of platypnea-orthodeoxia in a patient with minimal obstructive lung disease and progressive autonomic failure. We have shown our patient's symptoms to be the result of an orthostatic increase in ventilation-perfusion mismatching and to be corrected with fluid challenge.
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Fox et al. (1989) studied this question.
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