Key result
Depth-weighted optic attenuation framework reveals hidden electrophysiological features in a human cardiac ischemic model.
A novel depth-weighted optic attenuation visualization framework effectively reveals hidden electrophysiological features in a human cardiac ischemic model, aiding in the exploration of cardiac biophysical mechanisms.
May support optical mapping advances in ischemic models; leaves open human translation and clinical validation.
Although heart researches and acquirement of clinical and experimental data are progressively open to public use, cardiac biophysical functions are still not well understood. Due to the complex and fine structures of the heart, cardiac electrophysiological features of interest may be occluded when there is a necessity to demonstrate cardiac electrophysiological behaviors. To investigate cardiac abnormal electrophysiological features under the pathological condition, in this paper, we implement a human cardiac ischemic model and acquire the electrophysiological data of excitation propagation. A visualization framework is then proposed which integrates a novel depth weighted optic attenuation model into the pathological electrophysiological model. The hidden feature of interest in pathological tissue can be revealed from sophisticated overlapping biophysical information. Experiment results verify the effectiveness of the proposed method for intuitively exploring and inspecting cardiac electrophysiological activities, which is fundamental in analyzing and explaining biophysical mechanisms of cardiac functions for doctors and medical staff.
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Yang et al. (2016) studied Cardiac ischemia. Depth weighted optic attenuation visualization framework was evaluated on Visualization of hidden electrophysiological features in pathological tissue. A novel depth-weighted optic attenuation visualization framework effectively revealed hidden electrophysiological features in a human cardiac ischemic model.
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