Key result
Echo-derived TPVR strongly correlates with invasive measurements in a rat model of PAH.
Why the study?
Do echocardiographic parameters correlate with invasive measurements in evaluating pulmonary arterial hypertension severity in a rat model?
Do echocardiographic parameters correlate with invasive measurements in evaluating pulmonary arterial hypertension severity in a rat model?
Effect estimate: r = 0.92
p-value: p=<0.001
Non-invasive echocardiographic parameters, particularly pulmonary artery acceleration time and deceleration, correlate well with invasive measurements and can be used to evaluate PAH severity in a rat model.
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Supports echo-derived PVR in rat PAH models; leaves open human validation.
Koskenvuo et al. (2010) studied Pulmonary arterial hypertension (n=28). Echocardiography (TPVR, PAAT, PAD) vs. Invasive measurement (right heart catheterization) was evaluated on Correlation between echocardiographically derived total pulmonary vascular resistance (TPVR) and invasive measurement (r = 0.92, p=<0.001). Echocardiographically derived total pulmonary vascular resistance strongly correlated with invasive measurements (r = 0.92, P<0.001) in a rat model of pulmonary arterial hypertension.
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