Key result
Prophylactic RO-7 provides ~100% survival against lethal influenza in mice.
Why the study?
Does the PA endonuclease inhibitor RO-7 protect BALB/c mice from lethal challenge with influenza A or B viruses?
Population
BALB/c mice inoculated with influenza A/California/04/2009 (H1N1)pdm09 or B/Brisbane/60/2008 viruses
Comparison
PA endonuclease inhibitor RO-7 administered… vs null
Design
Preclinical
Authors
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May support clinical development of PA endonuclease inhibitors; leaves open human efficacy and safety.
Does the PA endonuclease inhibitor RO-7 protect BALB/c mice from lethal challenge with influenza A or B viruses?
The PA endonuclease inhibitor RO-7 demonstrates in vivo efficacy in protecting mice from lethal influenza A and B infections, supporting its potential as a novel antiviral therapy.
Jones et al. (2017) studied Influenza A or B virus infection. RO-7 was evaluated on Survival. Prophylactic RO-7 completely protected mice from lethal influenza A or B infection, while therapeutic administration resulted in 60% to 100% survival depending on treatment timing and dosage.
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