What is the clinical evidence from this study?

Study design: Observational. Population: Patients undergoing total hip or knee arthroplasty treated with dabigatran (n=10). Intervention: EcaTEM assay vs. Hemoclot assay (diluted thrombin time). Primary outcome: Correlation between CT EcaTEM and Hemoclot (correlation > 0.75).

What does this research mean for the field?

Clotting time measured by the novel point-of-care EcaTEM thromboelastometry assay correlates strongly (r > 0.75) with diluted thrombin time (Hemoclot) across prophylactic dabigatran concentration levels. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2017Transfusion Medicine and HemotherapyOpen Access

In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test

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Key result

EcaTEM clotting time correlates >0.75 with Hemoclot for measuring dabigatran in arthroplasty patients.

correlation > 0.75
n=10

Why the study?

Does the EcaTEM assay correlate with standard laboratory assays for measuring dabigatran concentrations in patients undergoing arthroplasty?

Population

10 patients undergoing total hip or knee arthroplasty treated with dabigatran for thromboprophylaxis

Comparison

Measurement of dabigatran concentration using… vs Standard laboratory assays

Design

Cohort

Follow-up

up to 3rd postoperative day

Authors

MKMareike Kristina KörberMedizinische Hochschule Brandenburg Theodor Fontane ELElisabeth LangerHumboldt-Universität zu Berlin MKMartin Köhr

Discussion

Member takes

Implication

EcaTEM may support point-of-care dabigatran assessment in arthroplasty; leaves open clinical utility pending prospective validation.

Study Design

Type

Observational (n=10)

Structured PICO

Does the EcaTEM assay correlate with standard laboratory assays for measuring dabigatran concentrations in patients undergoing arthroplasty?

Population

10 patients undergoing total hip or knee arthroplasty receiving dabigatran for thromboprophylaxis.

Exposure

Measurement of dabigatran concentration using EcaTEM assay (ecarin-based thromboelastometry)

Comparator

Standard laboratory assays (Hemoclot diluted thrombin time, activated partial thromboplastin time, thrombin time)

Outcome

Correlation of EcaTEM clotting time with standard laboratory assayssurrogate

Main Result

Effect estimate: correlation > 0.75

The EcaTEM assay is a valid point-of-care method that correlates well with the Hemoclot assay for detecting dabigatran levels, which may be useful in emergency situations.

Cite This Study

Körber et al. (2017) conducted an observational in Patients undergoing total hip or knee arthroplasty treated with dabigatran (n=10). EcaTEM assay vs. Hemoclot assay (diluted thrombin time) was evaluated on Correlation between CT EcaTEM and Hemoclot (correlation > 0.75). The EcaTEM assay clotting time showed a correlation > 0.75 with the Hemoclot assay for measuring dabigatran concentrations in patients undergoing arthroplasty.

synapsesocial.com/papers/6aa592184bcbe4818eeeb35b https://doi.org/10.1159/000470622

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In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider