Key result
Increased aortic pressure and right-heart volume raise LVEDP and lower stroke volume, attenuated by pericardiectomy.
This preclinical model demonstrates that increases in both right-heart volume and left ventricular afterload contribute to the inspiratory decrease in left ventricular stroke volume and increase in left ventricular end-diastolic pressure.
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Pericardial constraint modulates LV responses to right-heart and afterload changes; leaves open translation to human cardiorespiratory interactions.
Robotham et al. (1979) studied Effects of respiration on left ventricular performance. Increases in transmural aortic pressure and right-heart volume vs. Baseline or low volume was evaluated on Left ventricular end-diastolic pressure (LVEDP) and stroke volume (LVSV). Increases in transmural aortic pressure and right-heart volume caused increased left ventricular end-diastolic pressure and transient falls in stroke volume, attenuated by pericardiectomy.
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