Key result
The Mueller maneuver increased right ventricular end-diastolic volume by 10.4 +/- 2.3 ml (P<0.05) and left ventricular end-diastolic pressure by 3.6 mmHg (P<0.05) without changing LV volume.
p-value: p=<0.05
Respiratory maneuvers alter right ventricular volume, which subsequently affects the left ventricular pressure-volume relationship due to ventricular interdependence.
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Animal evidence supports ventricular interdependence during respiratory loading; leaves open translation to human cardiopulmonary physiology.
Santamore et al. (1984) studied this question. Respiratory maneuvers (Valsalva and Mueller maneuvers) vs. Normal respiration was evaluated on Right and left ventricular volumes and pressures (p=<0.05). The Mueller maneuver increased right ventricular end-diastolic volume by 10.4 +/- 2.3 ml (P<0.05) and left ventricular end-diastolic pressure by 3.6 mmHg (P<0.05) without changing LV volume.
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