Key result
Chordal-sparing MVR maintains better systolic and diastolic function than conventional MVR regardless of technique.
Why the study?
Does chordal-sparing mitral valve replacement preserve left ventricular contractility compared to conventional mitral valve replacement in a canine model?
Population
21 dogs studied 5 to 12 days after implantation of tantalum markers to measure left ventricular volume and…
Comparison
Chordal-sparing mitral valve replacement with… vs Conventional mitral valve replacement
Design
Preclinical
Follow-up
1 to 3 weeks
Authors
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Chordal preservation may better maintain LV function in MVR; animal data leaves human translation open.
Does chordal-sparing mitral valve replacement preserve left ventricular contractility compared to conventional mitral valve replacement in a canine model?
p-value: p=< 0.002
In a canine model, chordal preservation during mitral valve replacement maintained better systolic and diastolic function compared to conventional MVR, with no significant difference between anterior and posterior techniques.
Moon et al. (1994) studied Mitral valve replacement (n=21). Chordal-sparing MVR (anterior reattachment or posterior transposition) vs. Conventional MVR (total chordal excision) was evaluated on Physiologic intercept for end-systolic elastance (p=< 0.002). Chordal-sparing mitral valve replacement maintained better systolic and diastolic function than conventional MVR, with no substantial difference between anterior and posterior techniques.
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