What is the clinical evidence from this study?

Study design: Other. Intervention: Halothane vs. Conscious state (no halothane). Primary outcome: Pressor responses and haemodynamic effects (MAP, HR, TPR, CO) to L-NNA and L-NAME.

What does this research mean for the field?

Halothane selectively abolishes the pressor responses and attenuates the systemic and regional vasoconstrictor effects of nitric oxide synthase inhibitors in rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1993Journal of Cardiovascular Pharmacology

Selective Inhibition of Pressor and Haemodynamic Effects of NG-Nitro-L-Arginine by Halothane

View Full Paper

Ask AI

Bookmark

Key result

Halothane completely abolishes pressor responses to NO synthase inhibitors and attenuates vasoconstriction in rats.

Population

Rats (conscious and halothane-anaesthetized)

Comparison

Halothane anesthesia combined with intravenous… vs Conscious rats receiving the same pressor agents

Design

Preclinical

Authors

YWYong-Xiang Wang AAAly M. AbdelrahmanSultan Qaboos University CPCatherine C.Y. PangQueen Elizabeth Hospital Birmingham

Discussion

Member takes

Implication

Halothane modulates NO-dependent vascular tone in rats; leaves open relevance to human anesthesia and perioperative hemodynamics.

Structured PICO

Population

Conscious and halothane-anaesthetized rats evaluated for pressor responses to NO synthase inhibitors.

Intervention

Halothane anesthesia combined with intravenous bolus injections of NO synthase inhibitors (L-NNA 1-32 mg/kg, L-NAME 0.4-12.8 mg/kg), norepinephrine (0.25-8 micrograms/kg), or angiotensin II (0.02-0.64 micrograms/kg)

Comparator

Conscious rats receiving the same pressor agents

Outcome

Pressor responses including mean arterial pressure (MAP), total peripheral resistance (TPR), heart rate (HR), cardiac output (CO), and vascular conductancesurrogate

Halothane selectively inhibits the vasoconstrictor effects of NO synthase inhibitors, suggesting NO plays a role in maintaining peripheral vascular resistance.

Cite This Study

Wang et al. (1993) studied this question. Halothane vs. Conscious state (no halothane) was evaluated on Pressor responses and haemodynamic effects (MAP, HR, TPR, CO) to L-NNA and L-NAME. Halothane completely abolished the pressor responses to NO synthase inhibitors L-NNA and L-NAME and attenuated their vasoconstrictor effects in most vascular beds in rats.

synapsesocial.com/papers/6aa5b3bf5becb0bc28eec6ae https://doi.org/10.1097/00005344-199310000-00010

View Full Paper

Ask AI

Bookmark

Selective Inhibition of Pressor and Haemodynamic Effects of NG-Nitro-L-Arginine by Halothane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selective Inhibition of Pressor and Haemodynamic Effects of NG-Nitro-L-Arginine by Halothane

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider