Key result
Longer type 2 diabetes duration links to reduced vagal heart rate modulation in men only.
Why the study?
Is the duration of type 2 diabetes associated with heart rate variability differently in men and women?
Population
261 subjects (155 female, 106 male) with type 2 diabetes
Design
Cross-sectional
Authors
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Suggests possible sex differences in autonomic risk with diabetes duration; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=261)
Is the duration of type 2 diabetes associated with heart rate variability differently in men and women?
Effect estimate: standardised ss = -0.32
p-value: p=0.001
The duration of type 2 diabetes is inversely associated with heart rate variability in men but not in women, suggesting sex-based differences in early cardiac autonomic impairment.
Nolan et al. (2009) conducted a cross-sectional in Type 2 diabetes (n=261). Duration of type 2 diabetes was evaluated on Vagal-heart rate modulation (high frequency power) (standardised ss = -0.32, p=0.001). Duration of type 2 diabetes was inversely associated with vagal-heart rate modulation in men (standardised ss = -0.32, p=0.001 for high frequency power), but not in women.
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