Key result
Highest quartile admission serum sodium linked to ~237% greater in-hospital mortality in acute aortic dissection.
Why the study?
Higher serum sodium increases in-hospital mortality in many conditions, but its effect on postoperative in-hospital mortality in acute aortic dissection was unknown.
Does higher admission serum sodium increase postoperative in-hospital mortality in patients with acute aortic dissection?
Cohort (n=415)
Does higher admission serum sodium increase postoperative in-hospital mortality in patients with acute aortic dissection?
Hazard Ratio: 3.37 (95% CI 1.384–8.204)
p-value: p=0.007
Higher admission serum sodium is significantly associated with increased postoperative in-hospital mortality in patients with acute aortic dissection.
May warrant closer monitoring in acute aortic dissection; leaves open whether sodium correction improves survival.
BACKGROUND: Acute aortic dissection (AAD) is very fatal without surgical treatment. Higher serum sodium can increase in-hospital mortality of many diseases; however, the effect of serum sodium on postoperative in-hospital mortality in AAD patients remains unknown. METHODS: We collected a total of 415 AAD patients from January 2015 to December 2019. Patients were classified into four categories (Q1-Q4) according to the admission serum sodium quartile. The cox proportional hazards model evaluated the association between serum sodium and in-hospital mortality. All-cause in-hospital mortality was set as the endpoint. RESULTS: By adjusting many covariates, cox proportional hazards model revealed the in-hospital mortality risk of both Q3 and Q4 groups was 3.086 (1.242-7.671, P = 0.015) and 3.370 (1.384-8.204, P = 0.007) respectively, whereas the risk of Q2 group was not significantly increased. Univariate and multiple Cox analysis revealed that Stanford type A, serum glucose, α-hydroxybutyrate dehydrogenase and serum sodium were risk factors correlated with in-hospital death in AAD patients. CONCLUSION: The study indicates that the admission serum sodium of AAD patients has a vital impact on postoperative hospital mortality.
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Huang et al. (2021) conducted a cohort in Acute aortic dissection (n=415). Admission serum sodium (highest quartile) vs. Lowest quartile of admission serum sodium was evaluated on All-cause in-hospital mortality (HR 3.370, 95% CI 1.384-8.204, p=0.007). Admission serum sodium in the highest quartile was associated with increased postoperative in-hospital mortality in acute aortic dissection patients (HR 3.370; 95% CI 1.384-8.204; P=0.007).
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