Key result
Admission serum total cholesterol <4.00 mmol/L was associated with higher in-hospital mortality compared to ≥4.00 mmol/L in acute aortic dissection (11.7% vs 5.8%; HR 2.06; P=0.001).
Why the study?
Is lower admission serum total cholesterol associated with higher in-hospital mortality in patients with acute aortic dissection?
Cohort (n=1,492)
Is lower admission serum total cholesterol associated with higher in-hospital mortality in patients with acute aortic dissection?
Hazard Ratio: 2.06 (95% CI 1.33–3.19)
Absolute Event Rate: 11.7% vs 5.8%
p-value: p=0.001
Lower admission serum total cholesterol (<4.00 mmol/L) is strongly associated with increased in-hospital mortality in patients with Type-A acute aortic dissection.
OBJECTIVE: To find out the association between serum total cholesterol (TC) on admission and in-hospital mortality in patients with acute aortic dissection (AAD). METHODS: From January 2007 to January 2014, we enrolled 1492 consecutive AAD patients with serum TC measured immediately on admission. Baseline characteristics and in-hospital mortality were compared between the patients with serum TC above and below the median (4.00 mmol/L). Propensity score matching (PSM) was used to account for known confounders in the study. Cox proportional hazard model was performed to calculate the hazard ratio (HR) and 95% confidence interval (CI) for admission serum TC levels. RESULTS: With the use of PSM, 521 matched pairs of patients with AAD were yielded in this analysis due to their similar propensity scores. Patients with admission serum TC < 4.00 mmol/L, as compared with those with admission serum TC ≥ 4.00 mmol/L, had higher in-hospital mortality (11.7% vs. 5.8%; HR, 2.06; 95% CI, 1.33-3.19, P = 0.001). Stratified analysis according to Stanford classification showed that the inverse association between admission serum TC and in-hospital mortality was observed in patients with Type-A AAD (24.0% vs. 11.3%; HR, 2.18; 95% CI, 1.33 - 3.57, P = 0.002) but not in those with Type-B AAD (3.8% vs. 2.2%; HR, 1.71; 95% CI, 0.67 - 4.34, P = 0.261). CONCLUSIONS: Lower serum TC level on admission was strongly associated with higher in-hospital mortality in patients with Type-A AAD.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2016) conducted a cohort in acute aortic dissection (n=1,492). Admission serum total cholesterol < 4.00 mmol/L vs. Admission serum total cholesterol ≥ 4.00 mmol/L was evaluated on in-hospital mortality (HR 2.06, 95% CI 1.33-3.19, p=0.001). Admission serum total cholesterol <4.00 mmol/L was associated with higher in-hospital mortality compared to ≥4.00 mmol/L in acute aortic dissection (11.7% vs 5.8%; HR 2.06; P=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: