Key result
Noninvasive pupillary flash response successfully estimates autonomic nervous activity in a single subject.
A novel noninvasive method using pupillary flash response can estimate autonomic nervous activity.
Hypothesis-generating from single-subject data; larger validation studies required before clinical or research use.
This paper proposes a noninvasive method for estimating autonomic nervous activity from changes in dynamic parameters of a pupillary flash response. Our method is derived based on an analysis that clarifies the relationship between the autonomic nervous activity and the dynamic parameters using the human pupillary muscle plant model developed in our previous study. Moreover, we show that pupillary responses to an identical flash vary depending on the initial pupil diameter when evaluating autonomic nervous activity by means of changes in the dynamic parameters. The efficacy of this method is demonstrated by applying it to a subject whose autonomic nervous activity is modified by drugs affecting the autonomic nervous system.
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Yamaji et al. (2000) studied this question. Noninvasive method for estimating autonomic nervous activity by pupillary flash response was evaluated on Estimation of autonomic nervous activity. A noninvasive method for estimating autonomic nervous activity from dynamic parameters of a pupillary flash response was demonstrated to be efficacious in a single subject.
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