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All articles of this category Amidyl radicals generated from tributylstannane mediated homolysis of O-acyl hydroxamic acid derivatives 5a-b undergo tandem cyclisations to give pyrrolizidinones 6a-c and indolizidinones 7a-b respectively while 5c-d undergo monocyclisation to give β-lactam 10a and γ-lactam 11a respectively. On the other hand the reaction of 5d-f with Cu(OTf) 2 /DBN furnishes mixtures of reduction 10b , monocyclisation 10a and tandem cyclisation 9 products with the ratio dependant upon the nature of the O-acyl group and the solvent and concentration employed. amidyl radicals - cyclisation - copper complexes - hydroxamic acid derivatives
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Clark et al. (1999) studied this question.
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