Key result
LVDD and HFpEF are linked to non-classical monocyte shifts correlating with lower E' septal velocity.
Why the study?
Intermediate and non-classical monocyte activation in inflammatory conditions may contribute to LVDD and HFpEF, but the association of circulating monocyte subtypes and their activity with LVDD and HFpEF required investigation.
Are circulating monocyte subtypes and their activity associated with the presence of LVDD and HFpEF?
Observational (n=73)
Are circulating monocyte subtypes and their activity associated with the presence of LVDD and HFpEF?
p-value: p=0.008
LVDD and HFpEF are associated with a shift towards non-classical monocyte subtypes, which correlates with echocardiographic signs of diastolic impairment.
No takes yet. Share an insight, caveat, or question.
Monocyte subtypes may link inflammation to LVDD/HFpEF; hypothesis-generating and should not yet change practice.
Kessler et al. (2025) conducted an observational in Left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) (n=73). LVDD and HFpEF vs. Controls without LVDD or HFpEF was evaluated on Interleukin-6 secretion from PBMCs post-stimulation (p=0.008). LVDD and HFpEF are associated with a shift towards non-classical monocyte subtypes, which correlated with lower E' septal velocity (β = -0.15, p = 0.041).
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