Key result
Rheumatic mitral valve disease is linked to a higher TH17/Treg ratio correlating with elevated hs-CRP.
Why the study?
Is there an imbalance between TH17 and Treg cells in patients with rheumatic mitral valve disease compared to controls?
Case-Control (n=63)
Is there an imbalance between TH17 and Treg cells in patients with rheumatic mitral valve disease compared to controls?
p-value: p=0.0001
Rheumatic mitral valve disease is associated with an imbalance in TH17 and Treg cells, suggesting a potential role in its pathogenesis and a possible therapeutic target.
No takes yet. Share an insight, caveat, or question.
Altered TH17/Treg balance may contribute to RHD; hypothesis-generating and should not yet change practice.
Baş et al. (2014) conducted a case-control in Rheumatic mitral valve disease (n=63). Rheumatic mitral valve disease vs. Control subjects was evaluated on TH17/Treg ratio (p=0.0001). Rheumatic mitral valve disease was associated with a significantly higher TH17/Treg ratio compared with control subjects (P = 0.0001), which correlated with elevated hs-CRP levels.
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