Key result
HTLV-III virions selectively incorporate HLA class-II antigens and beta-2 microglobulin during budding from infected T-cells.
Population
H9 T-cell line used to produce HTLV-III virus
Design
Preclinical
Authors
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No immediate clinical implications for HIV care; extends retroviral budding observations yet leaves open in vivo pathogenic relevance.
The study suggests that budding HTLV-III virions selectively incorporate specific cellular antigens, particularly HLA class-II antigens, which may have relevance for the pathogenesis of the virus.
Hoxie et al. (1987) studied HTLV-III (AIDS-retrovirus) infection. Monoclonal antibodies to cellular antigens was evaluated on Reactivity in an ELISA of solubilized HTLV-III virus. HTLV-III virions selectively incorporate specific cellular antigens, particularly HLA class-II antigens and beta-2 microglobulin, during budding from infected H9 T-cells.
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