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This research explores the effects of HTLV-III infection on human T-cell lines carrying HTLV-I.

August 9, 1985Science

Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay

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Randomized trial evaluates cytopathogenic effects of HTLV-III in HTLV-I-carrying cells, suggesting implications for AIDS research.

This research explores the effects of HTLV-III infection on human T-cell lines carrying HTLV-I.
Infecting MT-2 and MT-4 cell lines with HTLV-III.
Observing cytopathogenic effects and cytotoxicity.
Using plaque-forming assays to titrate the virus.
Cytopathogenic effects and cytotoxicity were observed post-infection.
Rapid induction of HTLV-III antigens was detected through immunofluorescence.
Human antibodies against HTLV-III neutralized viral activity in assays.

Harada et al. (1985) studied this question.

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